Lead structures for applications in photodynamic therapy. Part 2: Synthetic studies for photo-triggered release systems of bioconjugate porphyrin photosensitizers
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چکیده
منابع مشابه
Porphyrin photosensitizers in photodynamic therapy and its applications
In 1841, the extraction of hematoporphyrin from dried blood by removing iron marked the birth of the photosensitizer. The last twenty years has witnessed extensive research in the application of photodynamic therapy (PDT) in tumor-bearing (or other diseases) animal models and patients. The period has seen development of photosensitizers from the first to the third generation, and their evolutio...
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Photodynamic therapy (PDT) has been used to treat several types of cancer, and comprises intravascular administration of photosensitizer, uptake by cancer cells, and followed by irradiation of light of appropriate wavelength. Although PDT takes advantage of relative retention of photosensitizer by cancer cells, effective delivery of photosensitizing drugs is of great concern. Several delivery s...
متن کاملActivatable Photosensitizers: Agents for Selective Photodynamic Therapy
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim wileyonlinelibrary.com 1604053 (1 of 11) tendencies to accumulate in tumor tissues to a greater extent than they do in normal tissues. On the other hand, irradiation light (in the red or near IR region) used for exciting the PS can be tightly focused on the tumor regions, essentially assuring the selective generation of singlet oxygen. Moreover,...
متن کاملNanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy
In this review, we address a highly interdisciplinary field: the use of nanomaterials as carriers for singlet oxygen photosensitizers and their potential applications in photodynamic therapy. In particular, recent advances in the use of nanoparticles including inorganic oxide-, metallic-, and polymer-based nanocomposites as photosensitizer carriers are highlighted. We review advantages and shor...
متن کاملLanthanide-doped upconversion nanoparticles electrostatically coupled with photosensitizers for near-infrared-triggered photodynamic therapy.
Lanthanide-doped upconversion nanoparticles (UCNPs) have recently shown great promise in photodynamic therapy (PDT). Herein, we report a facile strategy to fabricate an efficient NIR-triggered PDT system based on LiYF4:Yb/Er UCNPs coupled with a photosensitizer of a β-carboxyphthalocyanine zinc (ZnPc-COOH) molecule via direct electrostatic interaction. Due to the close proximity between UCNPs a...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2009
ISSN: 0040-4020
DOI: 10.1016/j.tet.2009.06.037